What is Mesotherapy

”Lipoplasty” is here to stay. To obtain the best results requires the best equipment and within this product category we offer highest quality equipment from Black & Black Surgical and Tulip Medical.

Mesotherapy is a non surgical cosmetic technique that uses numerous injections containing various types of medicines, vitamins, and minerals, enzymes, hormones, and plant extracts to rejuvenate and tighten skin, as well as remove excess fat. Some of these substances are FDA/EMA approved and some are not. While in the beginning of the time little was known or researched about the ingredients, today much is known about them and their impact on human skin.

Michel Pistor, a doctor in France, developed the technique in 1952. It was originally used to relieve pain. In the years since, it It is most popular in Southern Europe today but has gained popularity in the United States and other parts of the world too.

Today, mesotherapy is used to:

  • fade signs of aging such as wrinkles and lines
  • remove fat in areas like the stomach, thighs, buttocks, hips, legs, arms, and face
  • reduce cellulite
  • treat/reduce scars and strechmarks
  • treat discoloration challenges and issues such as hyper pigmentation.
  • tighten loose skin
  • recontour the body

The technique uses very fine needles to deliver a series of injections into the middle layer (mesoderm) of skin. The idea behind mesotherapy is that it corrects underlying issues like poor circulation and inflammation that cause skin damage.

Mesotherapy for anti-aging

“Black and Black Surgical” has more than 80 years of experience in the design of innovative plastic surgery instruments of ergonomic correctness and thus high functionality. “Black and Black Surgical” has partners who are some of the most respected names in plastic surgery, as the best innovative solutions and optimizations come from those who have and have had plastic surgery in their hands daily and for many years. These instruments are recognised and used by surgeons worldwide and include an extremely wide range of different instruments that ensure maximum accuracy and precision.

In addition to the instruments, Black & Black offers, as previously mentioned, equipment in the lipoplasty segment, including aspiration and infiltration pumps, tubes, harvesting and injection cannulas, etc.

List of possible ingredients:


This brightening agent compromised of 3 amino acids (Cysteine, Glycine & Glutamic Acid) is naturally produced in the body although levels of it decrease as we age. Aside from helping with skin tone, Glutathione is an antioxidant that protects against the effects of environmental damage from the sun and other elements.

Hyaluronic Acid:

As we age our body’s ability to retain moisture decreases. Luckily, Hyaluronic Acid has the capacity to hold 1000 times more water than its own weight and will definitely help with restoring both the way skin looks and the way it works.

Glycolic Acid:

Glycolic Acid is usually used in concentrations of around 1% in facial mesotherapy formulas in order to exfoliate dead skin cells as well as help increase collagen production.

Vitamin B3:

Also known as Niacinamide, Vitamin B3 is a cell-communicating ingredient; it helps cells work together well and function at their best. Among the numerous anti-aging benefits this ingredient offers is that it helps strengthen the skin’s structure as well as boosts its immunity to environmental damage.

Vitamin C:

A antioxidant, Vitamin C helps to fight free radicals, boost collagen synthesis, regulate melanin production (which helps those brown spots and acne marks) and also increases overall skin rejuvenation. L-Ascorbic Acid is one of the more common forms of Vitamin C used in mesotherapy formulas and is considered to be the most effective in terms of anti-aging results.

Vitamin E:

As an antioxidant with powerful anti-aging benefits, Vitamin E’s emollient nature nourishes the skin and also helps to prevent water loss. Facial mesotherapy formulas that use a combination of naturally derived alpha-tocopherol, mixed tocopherol and tocotrienols are among the most effective.

Vitamin A:

Retinoic Acid is the most powerful derivative of Vitamin A and is well known within the realm of anti-aging. Not only is it one of the most effective ingredients helping to repair skin damage, retinoic acid also helps with overall skin rejuvenation. As it’s such a potent ingredient, it’s usually found in extremely low percentages of about 0.01% in facial mesotherapy formulas.

Treatment and aftercare:

A mild topical anesthetic is usually applied to the areas being treated depending on the patients tolerance to pain. Using a micro-needle, the skincare practitioner will inject the areas being targeted multiple times.  As the needles only reach 4-6mm beneath the skin’s surface, discomfort is usually minimal and is often described as feeling like mosquito bites.

Depending on the severity of aging concerns, 3-5 sessions spaced 10-14 days apart are usually needed. In order to extend the lifespan of results a session every 1-3 months is generally recommended after the initial set of facial mesotherapy treatments. With regular maintenance expect results to last 1-2 years or longer.

Mesotherapy for Melasma / Pigmentation

Mesotherapy treatment for Melasma and other skin pigmentation disorders is delivered by micro-injection directly into the affected areas of the skin. This is the most effective way of targeting the problem, and shows the quickest results. It is most effective when used in conjunction with a peel, but both treatments can be used separately.

One of the solutions is a mixture of Glutathione and Vitamin C, which reduces damage to the epidermal cells and promotes the production of collagen, making the skin appear brighter.


  • Retynal Palmitate: Retinyl palmitate converts into retinol (or vitamin A), which in turn is converted into retinoic acid by specialized enzymes in the skin. Retinoic acid facilitates communication between cells, encouraging aging cells to continue their renewal process, and regenerate collagen and elastin to prevent the appearance of aging skin, wrinkles, and fine lines.
  • Glutathione: Inhibits melanin synthesis in reaction af tyrosinase by neutralizing free radicals and maintains exogenous antioxidants such as vitamins C and E in their reduced (active) forms which improves cell renewal. Is also known for its ability to lighten skin

Mesotherapy for Stretch Marks, Scars and Acne Scars

Stretch marks are scars underneath the skin that are most frequently caused by pregnancy or through gaining or losing weight. They occur in both women and men of all races and skin types. Stretch marks can have an unsightly cosmetic effect and cause many sufferers to become self-conscious. Scars can be created as a result of a medical procedure or by accidents to name a few. Acne scars occur after inflamed acne as the skin heals – often leaving fibrotic, course skin as a result.

Mesotherapy is a quick and effective way of improving the appearance of stretch marks and and scars regaining your confidence.

Mesotherapy treats stretch marks and scars with a cocktail of ingredients that mainly occur naturally in the body in order to promote healing and rejuvenation of the skin. The main ingredients are Pennywort, which heals and repairs the skin, Dexpanthenol and Elastin which help the skin to rejuvenate, and Organic Silicon, which the skin needs to form and strengthen its collagen fibres.

Examples of ingredients:

  • Ascorbic Acid: Antioxidants stimulates the production of collagen Out of the many beneficial forms of vitamin C, ascorbic acid is a superstar for its proven antioxidant properties that boost firmer-feeling skin.
  • Proteoglycans: molecules made up that shape the structure of the cells, and are joined to the cell membrane and the extracellular matrix.

Mesotherapy for Cellulite

Cellulite is not a disease but a chronic dysfunction and the reasons for its existence are multi-factorial. Mesotherapy is an effective treatment for cellulite and has been used for more than 50 years. The results can be pleasing, however it is often necessary to combine it with other treatments available such as radio frequency therapy, to achieve the best results. The treatment is carried out by injecting microscopic amounts of these blends, which work to tackle three of the most important factors that cause cellulite: fat, impaired circulation and damaged tissue.These are selected based on the specific case of cellulite in each patient and the doctor’s knowledge and resources at their disposal. Performing mesotherapy requires precise technique and the practitioner needs to fully understand the procedure. It is essential that the patient maintains a healthy lifestyle, participates in regular physical activity and eats a balanced diet in order to achieve optimal results each time.

How often?

The patient should be treated weekly for 10 to 12 weeks. The results are patient dependent, but usually seen at approximately the fifth week, with optimum results visible at the tenth or twelfth session. We advise that patients to undergo a maintenance treatment every six months. Mesotherapy is not only a therapeutic treatment, but also a preventative technique for cellulite. Don’t hesitate to involve other means of mesotherapy because, as mentioned earlier, no effective technique is used in isolation.

Treatment methods

Needles/syringes are the oldest and still the most used method of application. Different techniques include papule where injections are conducted at 1-2 mm depth and with the needle bevel upwards, nappage where injections are conducted at 2-4mm depth and at 30-60 degree angle and point-by-point/bolus technique where injections are deep at at 4-12mm depth and usually at 90 degree angle. Areas of skin are covered systematically and can be intensified at certain localities (wrinkles, etc.).

A dermal roller is a device that  activates the production of collagen with micro-needles, which improve the penetration of active principles. It promotes the production of new collagen layers and the reduction of pigmentation problems, acne scars and pore size. Healthcare professionals can use a roller with needles that go through the full dermis (1-5mm depending on the location in the body/face and what is the intention) while skin therapists are restricted to 1 mm depth and homecare rollers sold have usually 0.25-0.5mm deep needles. An area in the face/body gets rolled – usually horizontally, vertically and diagonally to ensure maximum needling and biostimulation. Ingredients are applied immediately on the rolled skin areas and massaged in.

 A meso gun is cable of simultaneous medication/ingredient administration and speed variation. The gun has standard meso needles (usually adjustable between 0.25-6mm) and syringes. Most meso guns has diffrent modes for example continuous injection, intermittet injections a raffale, point-by-point and mesoperfusion.

A derma pen, is a microneedle system which aims to tighten, lift and rejuvenate skin. The derma pens usually have adjustable needle depth and multi-speed functions. The pen is effective in treating areas such as periorbital areas (upper eye lids, around the mouth) where rollers or guns to certain extent are either too large or too cumbersome to be used. Needles vary from 12-40-nano allowing effective but small area treatments without having to do several passes.

 A device that uses technology based on electroporation ans iontophoresis – thus not using needles at all.  Alike the Meso Gun, pore perforation and infusion take place at the same time. Some discussion takes place as to the effectiveness of penetrating the skin layers and depth by using such a method compared to mechanical needle based options. Results are still to some extent debatable. Transdermic meso works with a line of cosmetics that contain ingredients that treat and protect the skin against problems such as stretch marks, anti-aging, cellulite, blemishes, muscle and joint problems.